Alpha 1 Antitrypsin, Random Stool (Sendout)
General Information
- Lab Name
- Alpha 1 Antitrypsin,fecal
- Lab Code
- RSA1A
- Epic Name
- Alpha 1 Antitrypsin, Fecal
- External Test Id
- A1AF
- Description
Useful For: Diagnosing protein-losing enteropathies, especially when used in conjunction with serum alpha-1-antitrypsin (AAT) levels as a part of AAT clearance studies.
Ordering Note: This test is for random stool specimens only. For testing on timed specimens, refer to separate entry Alpha 1 Antitrypsin Clearance, Feces and Serum (Sendout), OLTG #591.
- References
- Mayo Clinic Laboratories, Clinical and Interpretive Information: Alpha-1-Antitrypsin, Random, Feces
- Synonyms
- a-1-Antitrypsin Feces, A1A Stool, A1AT Stool, Alpha 1 Antitrypsin, Antitrypsin Stool
- Components
Interpretation
- Method
Nephelometry
- Reference Range
-
Units: mg/dL
Female Male Age Range Age Range 0- 0.0-54.0 0- 0.0-54.0 Effective date: 05/13/2005
- Ref. Range Notes
Interpretation:
Patients with protein-losing enteropathies generally have alpha-1-antitrypsin fecal concentrations over 100 mg/dL.
Borderline elevations above the normal range are equivocal for protein-losing enteropathies.
- Interferences and Limitations
Cautions:
The clearance studies using 24-hour fecal specimens and serum determinations are preferred as it normalizes the large range of serum alpha-1-antitrypsin (AAT) concentrations and the variability in random fecal AAT concentrations. In the absence of either a 24-hour fecal collection or a contemporary serum specimen, the fecal concentration of AAT can be used as a surrogate marker.
When gastric loss of AAT is suspected (eg, Menetrier disease), AAT clearance is not a reliable indicator of protein loss as AAT is sensitive to pH <3 and is rapidly destroyed. When gastric protein loss is suspected and the AAT clearance is normal, the recommendation is to repeat testing after starting an acid suppressive medication regime.
- References
- Mayo Clinic Laboratories, Clinical and Interpretive Information: Alpha-1-Antitrypsin, Random, Feces
Ordering & Collection
- Specimen Type
- Stool
- Collection
-
Collect 5 g RANDOM STOOL in a screw-capped stool collection container
- Handling Instructions
Outside Laboratories:
- Freeze stool at -20°C. If other tests are requested, submit a separate specimen for each.
Stability: Frozen (preferred): 14 days; Ambient: 14 days; Refrigerated: 14 days.
Reject Due To: Feces collected in any preservative or fixative.
- Quantity
-
Requested: 5 g stool
Minimum: 5 g stool
Processing
- Receiving Instructions
Freeze stool at -20°C.
- If a single unpreserved stool specimen is received for multiple tests, samples may be sent to Micro to be split prior to freezing. Include CID labels and directions for splitting (including minimum volumes). If there is insufficient sample, contact the provider to prioritize testing.
SPS Login Note: This test should be ordered on its own accession to prevent multiple stool tests from routing to the same container ID in Sunquest and to ensure proper interface batching. Separate stool specimens or aliquots must be submitted for each sendout test.
Sendouts:
- Order Mayo Test: A1AF.
- Interfaced: Yes.
Stability: Frozen (preferred): 14 days; Ambient: 14 days; Refrigerated: 14 days.
Reject Due To: Feces collected in any preservative or fixative.
- Misc Sendout
Performance
- Lab Department
- Sendouts Mayo Lab (FZ)(MAFZ)
- Frequency
- Performed: Monday through Friday. Report Available: 1-2 days from sample receipt at performing lab.
- Available STAT?
- No
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories
800-533-1710200 First Street Southwest
Rochester, MN 55901
Billing & Coding
- CPT Codes
- 82103
- LOINC
- 9407-8
- Interfaced Order Code
- UOW2279
- Interfaced Result Code
- UOW2279