Gynecologic Oncology (GYNPTH) Pathways
These four pathways are composed of paired tumor-germline testing for patients with gynecological cancers, following the UWMC Gynecological Oncology Pathways. The pathways include one or more tests from the following list, as determined by the agreed-upon diagnostic pathway: BROCA Paired Tumor Panel [BROCOP], targeted KRAS Mutations (DNA) [KRAS], BRAF Mutations [BRAF], MLH1 Promoter Hypermethylation [MLH1MT], Microsatellite Instability [MSI], UW OncoPlex Single Gene [OPG], UW OncoPlex Cancer Gene Panel [OPX], PDL1 IHC (send out).
These diagnostic pathways are defined by tumor type. See links below for testing specifics for each pathway:
- Ovarian, Fallopian, Peritoneal Pathway
- Primary Endometrial Carcinoma Pathway
- Recurrent + Metastatic Endometrial Carcinoma or Rare Tumor Pathway
- Recurrent + Metastatic Cervical, Vulvar, Vaginal Pathway
Specimen Requirements
Peripheral blood for Tumor Test Comparator Sample [OPCOMP] should be submitted.
Tumor tissue will be acquired by the laboratory.
The test order Gynecological Oncology Pathway [GYNPTH] will be initiated per the tumor type Gynecological Oncology Pathway (see above for diagnostic pathway details).
Requisitions and Contact Information
Requisitions
Instructions: Complete the appropriate requisition(s) and submit according to requisition instructions. The laboratory will start acquiring tissue when a completed requisition is received.
Contact Information
For pathway specific questions, including ordering help, please contact: genelab@uw.edu.
For pre-authorization questions, please contact: ngsbill@uw.edu.
For pre-analytical specimen type questions, please contact: teamgps@uw.edu.
Fax number: (206) 616-4584
Associated Tests
| Code | Name | Specimen | Comments |
|---|---|---|---|
| BRAF | BRAF Mutations | Tumor Tissue, Purified DNA, accompanied ... | |
| BROCOP | BROCA Paired Tumor Panel | Formalin-Fixed Paraffin Embedded Tumor T... | |
| KRAS | KRAS Mutations (DNA) | Tumor Tissue, Purified DNA, accompanied ... | |
| MSI | Microsatellite Instability | Tumor Tissue, Purified DNA, Bone Marrow,... | |
| MLH1MT | MLH1 Promoter Hypermethylation | Formalin Fixed Paraffin Embedded tissue ... | |
| OPCOMP | Tumor Test Comparator Sample | Peripheral blood | |
| OPX | UW OncoPlex Cancer Gene Panel | Tumor Tissue, Purified DNA, Bone Marrow,... | |
| OPG | UW OncoPlex Single Gene | Tumor Tissue, Purified DNA, Bone Marrow,... |
Last updated 2024-10-15T16:50:16.675680+00:00