Hantavirus IgG and IgM Antibodies (Sendout)

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General Information

Lab Name
Lab Code
228
External Test Id
HANGM
Description

Useful For: Aiding in the diagnosis of Hantavirus infection.

Highlights: This test detects IgM and IgG class antibodies in serum against two Hantavirus strains, Sin Nombre virus and Andes virus. However, it does not differentiate between the two strains.

Ordering Requirements: This test requires approval from the Laboratory Medicine Resident (LMR) on-call. Contact the LMR via the paging officer at 206-598-6190.

References
Synonyms
Andes Virus, FHVGM, HANGM, Hantavirus Antibody, Hantavirus Pulmonary Syndrome, Hemorrhagic Fever with Renal Syndrome, Sin Nombre Virus
Components

Interpretation

Guidelines
Method

Enzyme-Linked Immunosorbent Assay (ELISA)

Reference Range
Ref. Range Notes

Reference Values:

IgM: Negative
IgG: Negative

Interpretation:

IgM result IgG result Interpretation
Negative Negative No antibodies to Hantavirus (Sin Nombre or Andes strains) detected. False-negative results may occur in patients tested too soon following infection or in immunocompromised patients.
Negative Borderline Possible detection of IgG against Hantavirus (Sin Nombre or Andes strains, unable to differentiate). Consider repeat testing on a new specimen to confirm.
Negative Positive IgG against Hantavirus (Sin Nombre or Andes strains, unable to differentiate) detected. Results suggest prior exposure or infection with Hantavirus.
Borderline Negative Possible detection of IgM against Hantavirus (Sin Nombre or Andes strains, unable to differentiate). Consider repeat testing on a new specimen to confirm.
Borderline Borderline Possible detection of IgM and IgG against Hantavirus (Sin Nombre or Andes strains, unable to differentiate). Consider repeat testing on a new specimen to confirm.
Borderline Positive IgG against Hantavirus (Sin Nombre or Andes strains, unable to differentiate) detected. Possible detection of IgM against Hantavirus (Sin Nombre or Andes strains, unable to differentiate). Consider repeat testing on a new specimen to confirm IgM results.
Positive Negative IgM against Hantavirus (Sin Nombre or Andes strains, unable to differentiate) detected. Results suggest recent infection with Hantavirus.
Positive Borderline IgM against Hantavirus (Sin Nombre or Andes strains, unable to differentiate) detected. Possible detection of IgG against Hantavirus (Sin Nombre or Andes strains, unable to differentiate). Consider repeat testing on a new specimen to confirm IgG results.
Positive Positive IgM and IgG against Hantavirus (Sin Nombre or Andes strains, unable to differentiate) detected. Results suggest recent infection with Hantavirus.
Interferences and Limitations

Cautions:

False-negative results may occur in patients that are tested either too soon following infection or are significantly immunocompromised.

This assay detects IgM and IgG antibodies against antigens from the Sin Nombre and Andes Hantavirus strains; however, it will not differentiate between the two strains. It is unknown if this assay will detect antibodies to other Hantavirus strains.

Results must be interpreted alongside epidemiological exposure history and clinical presentation and diagnosis should not be made solely on serologic results from this assay.

False-positive results may occur in patients with recent cytomegalovirus infection.

Results from this assay are qualitative only.

References

Ordering & Collection

Specimen Type
Blood
Collection

3 mL blood in GOLD SST (preferred) or RED TOP tube

Approval Required
Laboratory Medicine Resident (LMR) approval required.
Handling Instructions

Outside Laboratories: Centrifuge sample and aliquot serum into a separate plastic vial. Refrigerate serum while awaiting shipment. Transport with a cold pack.

Stability: Refrigerated (preferred): 21 days; Frozen: 30 days; Ambient: 7 days.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus, heat-inactivated specimen.

Quantity
Requested: 0.6 mL serum
Minimum: 0.5 mL serum

Processing

Receiving Instructions

Centrifuge and aliquot serum into a separate vial. Refrigerate serum.

Login: SEND1-;REFRIG SERUM

  • RSNDT1: MAYOSD
  • RSTYP1: SRM
  • RTSRQ1: ;Hantavirus IgG and IgM Antibodies (Mayo Test HANGM)

Sendouts:

  • Order Mayo Test: HANGM

Stability: Refrigerated (preferred): 21 days; Frozen: 30 days; Ambient: 7 days.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus, heat-inactivated specimen.

Misc Sendout

Performance

Lab Department
Frequency
Performed: Wednesday, Friday. Report Available: 1-5 days from sample receipt at Mayo Clinic Labs.
Available STAT?
No
Performing Location(s)
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-1710

3050 Superior Drive NW
Rochester, MN 55901

Billing & Coding

Billing Comments

CPT: 86790 x 2