Plasminogen Activator Inhibitor Antigen 1 (PAI-1)

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General Information

Lab Name
Lab Code
608
External Test Id
36555
Description

Clinical Significance: Increased activity is associated with increased risk of arterial thrombosis, such as with unexplained premature myocardial infarction. As an acute phase reactant, the activity is increased after an acute event. Studies suggest PAI-1 may be a prognostic marker in early stage breast cancer.

Synonyms
36555, 59766P, PAI-1, PAI1, PAIAG
Components

Interpretation

Method

Enzyme Immunoassay (EIA)

Reference Range
Ref. Range Notes

Reference Range: 4-43 ng/mL

Ordering & Collection

Specimen Type
Plasma
Collection

5 mL blood in BLUE TOP (3.2 % Sodium Citrate) Tube

Note: If no other samples are to be collected, draw a discard (non-additive tube) tube prior to drawing coagulation specimens.

Expedite transport to the laboratory. The lab must receive and process specimen within 2 hours of blood collection.

Handling Instructions

Outside Laboratories:

  • Centrifuge sample for 15 minutes.
  • Remove plasma and centrifuge plasma for another 15 minutes.
  • Transfer plasma into a separate plastic vial within 2 hours of collection using a plastic Pasteur pipette. Do not use glass tubes or glass Pasteur pipettes, as glass can activate the clotting cascade. Freeze plasma (minimum 0.5 mL) at -20°C to -80°C.
  • Send Frozen on dry ice.

Stability: Frozen (-70°C): 1 year; Frozen (-20°C): 30 days; Refrigerated: 2 hours; Ambient: Unacceptable.

Reject Criteria: Received refrigerated or ambient.

Quantity
Requested: 1 mL sodium citrate plasma
Minimum: 0.5 mL sodium citrate plasma

Processing

Receiving Instructions

UW-MT & HMC Instructions: Forward specimen to Coag bench for processing.

Coagulation: Within 2 hours of collection, double-centrifuge sample and transfer 1 mL (0.5 mL min.) plasma to a separate plastic vial. Freeze plasma at -70°C (Sendouts frozen rack).

Login: SEND1-;FREEZE

  • RSNDT1: QNICH
  • RSTYP1: PLS
  • RTSRQ1: ;Plasminogen Activator Inhibitor Antigen (Quest Test 36555)

Sendouts, order Quest Test: 36555.

Stability: Frozen (-70°C): 1 year; Frozen (-20°C): 30 days; Refrigerated: 2 hours; Ambient: Unacceptable.

Reject Criteria: Received refrigerated or ambient.

Misc Sendout

Performance

Lab Department
Frequency
Set up: Tuesday. Report Available: 3-10 days.
Available STAT?
No
Performing Location(s)
Sendout Quest Diagnostics Nichols Institute
800-642-4657

33608 Ortega Highway
San Juan Capistrano, CA 92675

Billing & Coding

Billing Comments

CPT: 85415; LOINC Code: 22758-7