Galactose Alpha 1,3 Galactose, IgE (Sendout)

General Information

Lab Name

Lab Code

RALGAL

Epic Name

Galactose-Alpha-1,3-Galactose, IgE (Sendout)

External Test Id

ALGAL

Description

Useful For:

As an aid in diagnosis of an IgE mediated hypersensitivity allergy to red meat or meat-derived products such as beef, pork, venison, and gelatin
This test is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists.
This test is not useful for patients in whom the medical management does not depend upon identification of allergen specificity.

Highlights:

The presence of IgE antibodies against galactose-alpha-1,3-galactose (alpha-gal) is associated with red meat allergy.
Individuals with IgE antibodies against alpha-gal might develop anaphylactic reactions to the drug cetuximab.
Other meat allergen IgE antibody tests may be considered in addition to galactose-alpha-1,3-galactose IgE antibody testing in cases of suspected red meat allergy.

Ordering Note: Non-orderable Sendout battery included in package Galactose Alpha 1,3 Galactose, IgE (Sendout) [RALGAG].

Synonyms

ALGAL, alpha gal, Alpha Gal IgE, Alpha-Gal, alphagal, Galactose IgE, Galactose-alpha-1 3

Components

Code	Name
RALGLI	Galactose Alpha 1,3 Galactose, IgE

Method: Fluorescence Enzyme Immunoassay (FEIA)
Reference Range: See individual components
Interferences and Limitations: Cautions:

Some individuals with clinically insignificant sensitivity to allergens may have measurable levels of IgE antibodies in serum, and results must be interpreted in the clinical context.

False-positive results for IgE antibodies may occur in patients with markedly elevated serum IgE (>2500 kU/L) due to nonspecific binding to allergen solid phases.

Specimen Type: Blood
Collection: 3 mL blood in RED TOP tube or GOLD SST
Quantity: Requested: 0.5 mL serum + 0.5 mL serum for UW438
Minimum: 0.3 mL serum

Receiving Instructions

Centrifuge sample and transfer serum to two separate plastic vials. If sample volume is low, prioritize the sendout test.

Sendouts:

Stability: Refrigerated (preferred): 14 days; Frozen: 90 days; Ambient: Unacceptable.

Lab Department

Sendouts Mayo Lab (RF)(MARF)

Frequency

Performed: Monday - Friday. Report Available: 1-3 days.

Available STAT?

Performing Location(s)

Sendout	Mayo Clinic Laboratories (Superior Drive) 800-533-1710 3050 Superior Drive NW Rochester, MN 55901