CIDP/NP Evaluation (Sendout)

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General Information

Lab Name
CIDP/NP Evaluation (Sendout)
Lab Code
RCIDP
Epic Name
CIDP/NP Evaluation (Sendout)
External Test Id
CIDP
Description

Useful For: Evaluating for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and related demyelinating peripheral neuropathies.

Ordering Guidance: This panel includes Contactin-1 IgG Cell Binding Assay and Neurofascin-155 IgG4 by Flow Cytometry and is the preferred test for CIDP. To order Contactin-1 or Neurofascins individually, or to order neurofascin isoforms -140, -155, and -186, refer to separate test Contactin-1 and Neurofascin 140, 155 & 186 Antibodies (Sendout). Laboratory Medicine Resident (LMR) approval is required to send testing to Neuromuscular Clinical Lab at Washington University.

Ordering Requirements: Pre-approved for UW Medicine Neurology locations. All other ordering locations require Laboratory Medicine Resident (LMR) approval.

References
Synonyms
Autoimmune Peripheral neuropathy, Chronic Inflammatory Demyelinating Polyradiculoneuropathy/Nodopathy Evaluation, CIDP, CISP, CNTN1, Contactin-1 IgG, Demyelinating neuropathy, Immune Neuropathy, Neurofascin-155 IgG4, Polyneuropathy, Polyradiculoneuropathy, Polyradiculopathy
Components
Code Name
RCIDPI CIDP/NP Evaluation Interpretation
RCONT1 Contactin 1 IgG, Cell Binding Assay
RNF155 Neurofascin 155 IgG4, Flow Cytometry

Interpretation

Method

Contactin-1 IgG: Cell Binding Assay (CBA)

Neurofascin-155 IgG4: Flow Cytometry (FCM)

Reference Range
See individual components
Ref. Range Notes

Reference Values:

Contactin-1 IgG: Negative
Neurofascin-155 IgG4: Negative

Interpretation:

Seropositivity for contactin-1 IgG is consistent with an immune-mediated demyelinating polyradiculoneuropathy/polyradiculopathy.

Seropositivity for neurofascin-155 IgG4 is consistent with an immune-mediated demyelinating polyradiculoneuropathy.

Interferences and Limitations

Cautions:

  • A negative result does not exclude an immune mediated demyelinating neuropathy.
  • This test should only be utilized in the appropriate clinical context.
  • The use of immunotherapy prior to sample collection may negatively impact the sensitivity of this assay.
References

Ordering & Collection

Specimen Type
Blood
Collection

9 mL blood in RED TOP tube

  • Also Accepted: GOLD SST
Approval Required
Pre-approved for UW Medicine Neurology locations. All other ordering locations require Laboratory Medicine Resident (LMR) approval.
Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum into a separate plastic vial. Refrigerate serum while awaiting shipment. Transport with a cold pack.

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus.

Quantity
Requested: 3 mL serum
Minimum: 2 mL serum

Processing

Receiving Instructions

Centrifuge sample and aliquot serum into a separate plastic vial. Refrigerate serum.

Sendouts:

  • Order Mayo Test: CIDP
  • Interfaced: Yes [Interfaced: Yes; Worksheet: MARF]

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus.

Misc Sendout

Performance

Lab Department
Sendouts Mayo Lab (RF)(MARF)
Frequency
Performed: Monday, Friday (Neurofascin) and Monday through Thursday, Sunday (Contactin-1). Report Available: 5-10 days from sample receipt at Mayo Clinical Lab.
Available STAT?
No
Performing Location(s)
Sendout Mayo Clinic Laboratories
800-533-1710

200 First Street Southwest
Rochester, MN 55901

Billing & Coding

CPT Codes
86255x2
LOINC
18727-8