VDRL, CSF (Sendout)

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General Information

Lab Name
VDRL, CSF
Lab Code
RCVDRL
Epic Name
VDRL, CSF (Sendout)
External Test Id
0050206
Description

Test Information: The Venereal Disease Research Laboratory (VDRL) is a nontreponemal serologic test for syphilis that uses a cardiolipin-cholesterol-lecithin antigen to detect reaginic antibodies. The presence of neurosyphilis in untreated patients can be detected by the presence of pleocytosis, elevated protein, and a positive VDRL.

    Useful For: Aiding in the diagnosis of neurosyphilis.

      Test Algorithm: If the VDRL is weakly reactive or reactive, a titer will be performed at additional charge.

        ***Order Alert: Effective 05/22/2025, this test is no longer available at Mayo Clinic Laboratories. Samples will be forwarded to ARUP Laboratories for test Treponema pallidum (VDRL), Cerebrospinal Fluid with Reflex to Titer and reported under Reference Laboratory Test 1 (SEND1).***

        Synonyms
        0050206, Neurosyphilis, RPR-CSF, Soft-VDSF, Syphilis, VDSF
        Components
        Code Name
        CVD VDRL, CSF

        Interpretation

        Method

        Semi-Quantitative Flocculation

        Reference Range
        See individual components
        Ref. Range Notes
        Reference Interval: Nonreactive

        Ordering & Collection

        Specimen Type
        CSF, Cerebrospinal Fluid, Spinal Fluid
        Collection

        0.5 mL CSF in a sterile vial

        Handling Instructions

        Outside Laboratories: Freeze 0.5 mL CSF in a plastic vial at -20°C.

        Stability: Frozen: 1 year; Refrigerated: 2 weeks; Ambient: 48 hours.

        Unacceptable Conditions: Other body fluids. Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.

        Quantity
        Requested: 0.5 mL CSF
        Minimum: 0.4 mL CSF

        Processing

        Receiving Instructions

        Freeze 0.5 mL CSF in a plastic vial at -20°C.

        Sendouts:

        • Temporary Workflow: Order ARUP Test: 0050206 (ARUPConnect manual order)
        • CAST will add a SEND1 in Sunquest upon result receipt.

        Stability: Frozen: 1 year; Refrigerated: 2 weeks; Ambient: 48 hours.

        Unacceptable Conditions: Other body fluids. Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.

        Misc Sendout

        Performance

        Lab Department
        Sendouts Mayo Lab (FZ)(MAFZ)
        Frequency
        Performed: Sunday through Saturday. Reported: 1-4 days from sample receipt at ARUP Laboratories.
        Available STAT?
        No
        Performing Location(s)
        Sendout ARUP Laboratories, Inc.
        800-522-2787

        500 Chipeta Way
        Salt Lake City, UT 84108

        Billing & Coding

        CPT Codes
        86592
        LOINC
        5290-2
        Interfaced Order Code
        UOW4104
        Billing Comments

        If this test is reactive or weakly reactive, a VDRL titer will be performed at additional charge.