Insulin Antibody (Sendout)
General Information
- Lab Name
- Insulin Antibody (Sendout)
- Lab Code
- RINSG
- Epic Name
- Insulin Antibody (Sendout)
- External Test Id
- 0099228
- Description
Ordering Recommendation: This test detects the presence of antibodies to endogenous or exogenous insulin analogues. Testing is not recommended for patients receiving insulin >2 weeks, as insulin antibody formation may occur. Many cases of autoimmune diabetes mellitus are associated with specific autoantibodies, including Insulin Antibody (Sendout) [RINSG], GAD65 Ab Assay (Sendout) [RGD65], IA-2 Antibody (Sendout) [RIA2A], and Zinc Transporter 8 Antibody (Sendout) [RZNT8A]. Presence and persistence of two or more of these autoantibodies predicts clinical DM. When evaluating for autoimmune diabetes mellitus, perform testing for at least two autoantibodies (typically, GAD65 in combination with another of the above autoantibody tests).
- References
- ARUP Consult Topic: Diabetes Mellitus - Type 1, Type 2, and Gestational
- Synonyms
- 0099228, Anti-Insulin, FINAB, Human Insulin, INAB, Insulin Ab
- Components
-
Code Name RINAN Insulin Antibody
Interpretation
- Method
Semi-Quantitative Radioimmunoassay
- Reference Range
- See individual components
- Ref. Range Notes
Reference Interval: 0.0-0.4 Kronus Units/mL Interpretive Data: A value greater than 0.4 Kronus Units/mL is considered positive for Insulin Antibody. Kronus units are arbitrary. Kronus Units = U/mL.
- Interferences and Limitations
This assay is intended for the semi-quantitative determination of antibodies to endogenous insulin or antibodies to exogenous insulin in human serum. Antibodies to exogenous insulin therapies may be detected using this method. The magnitude of the measured result is not related to disease progression. Results should be interpreted within the context of clinical symptoms.
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
3 mL blood in a RED TOP tube or GOLD SST
- Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Freeze serum at -20°C while awaiting shipment. Transport on dry ice.
Stability: Frozen (preferred) 2 months; Refrigerated: 1 week; Ambient: 24 hours.
Unacceptable Conditions: Plasma. Hemolyzed or lipemic specimens.
- Quantity
-
Requested: 0.5 mL serum
Minimum: 0.1 mL serum
Processing
- Receiving Instructions
Centrifuge sample and aliquot serum to a separate plastic vial. Freeze serum at -20°.
Sendouts:
- Order ARUP Test: 0099228
- Interfaced: Yes [Interface: 602; Department: ARPZ]
Stability: Frozen (preferred) 2 months; Refrigerated: 1 week; Ambient: 24 hours.
Unacceptable Conditions: Plasma. Hemolyzed or lipemic specimens.
- Misc Sendout
Performance
- Lab Department
- Sendouts ARUP Lab (FZ)(ARPZ)
- Frequency
- Performed: Tuesday, Wednesday, Friday. Reported: 2-5 days from sample receipt at ARUP Laboratories.
- Available STAT?
- No
- Performing Location(s)
-
Sendout ARUP Laboratories, Inc.
800-522-2787500 Chipeta Way
Salt Lake City, UT 84108
Billing & Coding
- CPT Codes
- 86337
- LOINC
- 56546-5
- Interfaced Order Code
- UOW2419