Insulin Antibody (Sendout)

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General Information

Lab Name
Insulin Antibody (Sendout)
Lab Code
RINSG
Epic Name
Insulin Antibody (Sendout)
External Test Id
0099228
Description

Ordering Recommendation: This test detects the presence of antibodies to endogenous or exogenous insulin analogues. Testing is not recommended for patients receiving insulin >2 weeks, as insulin antibody formation may occur. Many cases of autoimmune diabetes mellitus are associated with specific autoantibodies, including Insulin Antibody (Sendout) [RINSG], GAD65 Ab Assay (Sendout) [RGD65], IA-2 Antibody (Sendout) [RIA2A], and Zinc Transporter 8 Antibody (Sendout) [RZNT8A]. Presence and persistence of two or more of these autoantibodies predicts clinical DM. When evaluating for autoimmune diabetes mellitus, perform testing for at least two autoantibodies (typically, GAD65 in combination with another of the above autoantibody tests).

References
Synonyms
0099228, Anti-Insulin, FINAB, Human Insulin, INAB, Insulin Ab
Components
Code Name
RINAN Insulin Antibody

Interpretation

Method

Semi-Quantitative Radioimmunoassay

Reference Range
See individual components
Ref. Range Notes
Reference Interval: 0.0-0.4 Kronus Units/mL

Interpretive Data: A value greater than 0.4 Kronus Units/mL is considered positive for Insulin Antibody. Kronus units are arbitrary. Kronus Units = U/mL.

Interferences and Limitations

This assay is intended for the semi-quantitative determination of antibodies to endogenous insulin or antibodies to exogenous insulin in human serum. Antibodies to exogenous insulin therapies may be detected using this method. The magnitude of the measured result is not related to disease progression. Results should be interpreted within the context of clinical symptoms.

References

Ordering & Collection

Specimen Type
Blood
Collection

3 mL blood in a RED TOP tube or GOLD SST

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Freeze serum at -20°C while awaiting shipment. Transport on dry ice.

Stability: Frozen (preferred) 2 months; Refrigerated: 1 week; Ambient: 24 hours.

Unacceptable Conditions: Plasma. Hemolyzed or lipemic specimens.

Quantity
Requested: 0.5 mL serum
Minimum: 0.1 mL serum

Processing

Receiving Instructions

Centrifuge sample and aliquot serum to a separate plastic vial. Freeze serum at -20°.

Sendouts:

  • Order ARUP Test: 0099228
  • Interfaced: Yes [Interface: 602; Department: ARPZ]

Stability: Frozen (preferred) 2 months; Refrigerated: 1 week; Ambient: 24 hours.

Unacceptable Conditions: Plasma. Hemolyzed or lipemic specimens.

Misc Sendout

Performance

Lab Department
Sendouts ARUP Lab (FZ)(ARPZ)
Frequency
Performed: Tuesday, Wednesday, Friday. Reported: 2-5 days from sample receipt at ARUP Laboratories.
Available STAT?
No
Performing Location(s)
Sendout ARUP Laboratories, Inc.
800-522-2787

500 Chipeta Way
Salt Lake City, UT 84108

Billing & Coding

CPT Codes
86337
LOINC
56546-5
Interfaced Order Code
UOW2419